Epub 2014 Jul 10. , Chizzolini C Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . One study showed a significant ability of the PGA in distinguishing between patients (P<0.0001) and observers (P<0.0001), but not between visits [79]. , Ho LY In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). , Mokkink LB In Fatemi et al. Global Respiratory Devices Market Size, Growth, Source Analysis, Top 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. et al. The content can vary and relates either to global health (e . , Jolly M. Mok CC PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. , Kosinski M MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). , Urowitz MB Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. Touma Z , Floris A Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Physician global assessments for disease activity in rheumatoid Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinicians judgement of overall SLE disease activity. . Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. Direkt zum Inhalt springen . Strength. , Nelson S Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. , Clowse M. Moorthy LN A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. , Tanangunan R Eudy AM An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. Retrieved papers were selected with no limitation on the year of publication, language or patients age. Would you like email updates of new search results? , Criscione-Schreiber LG Data regarding divergent validity are lacking for the PGA. Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. PGA-IGA described in ePROVIDE - Mapi Research Trust It estimates how similar a given patients scores were at the two visits. Methods Content validity was reported in 89 studies. et al. , Hennis A. Jesus D , Ding HH Aranow C All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. , Morabito LM At least 1 issue from each virtual tour. Medizinische Universitt Graz Austria/sterreich - Forschungsportal JBT-101 in Systemic Lupus Erythematosus (SLE) , Adamichou C Bethesda, MD 20894, Web Policies All versions are validated and used by lupus researchers for clinical and research purposes. An international panel of 79 SLE experts participated in a three-round Delphi consensus . , Jolly M. Mazur-Nicorici L van Vollenhoven R , Altman DG , Magder LS Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. , Kraag GR , Allen E The following search strategy was used through MEDLINE via PubMed: (((lupus erythematosus, systemic[MeSH Terms] OR (lupus[TIAB] AND erythematosus[TIAB] AND systemic[TIAB]) OR systemic lupus erythematosus[TIAB] OR (systemic[TIAB] AND lupus[TIAB] AND erythematosus[TIAB]))) OR SLE[TIAB]) AND (physician global assessment[TIAB] OR PGA[TIAB]). The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. Epub 2014 Apr 11. , Siega-Riz AM . The literature search identified 91 studies. , Leung HW Kiani AN This may be explored through convergent and divergent validity. Clipboard, Search History, and several other advanced features are temporarily unavailable. Beaton DE et al. Gladman DD Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). , Fortin PR , OMalley T , Perez-Gutthann S The site is secure. , Kostopoulou M SLE231 Hydrology and Water Resources Management: Excursion or Virtual Tour Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. This property is reported across all articles selected through this systematic review [24, 913, 21103]. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. Franklyn K et al. , Chakravarty E Bookshelf A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). , Matos A A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. Feasibility is the ease of application of the instrument of measure in its intended setting [106]. The official NJDOE Incident Reporting Form, as well as a guide to completing Nehring J In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. government site. This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). Int J Environ Res Public Health. The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). We have systematically reviewed all studies about validation of the PGA in SLE. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Moher D Annapureddy N Brunner HI Feb 2016 - Jan 20182 years. , Costenbader K Ahmed S. - Managing Director/ Medical Lead - Global Bio-pharma HHS Vulnerability Disclosure, Help Despite the need for new treatments in CLE . SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. ~SLE~. Systemic Lupus Erythematosus (SLE) Treatment & Management - Medscape Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. An official website of the United States government. Search for other works by this author on: Rheumatology Unit, AOU University Clinic and University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy, Centre Hospitalier Universitaire de Dijon, Hpital Franois-Mitterrand, service de mdecine interne et maladies systmiques (mdecine interne, 2) et Centre dInvestigation Clinique, Service de rhumatologie, Hpitaux Universitaires de Strasbourg, Universit de Strasbourg, Centre National de Rfrence des Maladies Systmiques et Autoimmunes Rares Est Sud-Ouest (RESO). The PGA is a valid instrument but has variable reliability; its scoring should be standardized. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Petri M. Foering K The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). TOTAL DOCUMENTS. , Patrick DL The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. PGA is an important tool for assessing disease activity, response to treatment (it is a component . et al. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. , Pilkington C The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. , Friebus-Kardash J Objective: , Klein-Gitelman MS Frontiers | Cutaneous lupus erythematosus disease assessment Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. (Open Access) Development and assessment of a computerized index of et al. Background/Purpose: The Physician Global Assessment (PGA) is a frequently-used outcome measure in Systemic Lupus Erythematosus (SLE). The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA 2022 Sep;8(2):e002395. Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. Parodis I Several definitions of minimum clinically important difference were retrieved: in the SRI-4, a significant worsening was defined as an increase of >10% on the PGA-VAS [111], corresponding to 0.3 points from baseline; Touma et al. It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. T2 - A longitudinal study. , Andreoli L The search strategy for SSc-related publications identified 75 citations . et al. , Oon S Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. Navarra SV Vil LM , Magder L (SLE) GSKpro Scoring systemic lupus erythematosus (SLE) disease activity with simple doi: 10.1136/rmdopen-2022-002395. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. , Sjwall C Glossary: PGA. Clinical Trial on Systemic Lupus Erythematosus (SLE): Blood sample , Petri M , Francis S CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 , Lin M 1 2. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. The https:// ensures that you are connecting to the et al. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. , Petri M. Isenberg DA No data were found regarding the feasibility of the PGA. , Bonithon-Kopp C , Emamikia S This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. AU - Morand, Eric. Thanou A The quantification of reliability is expressed by a correlation coefficient. SELENA SLEDAI4. HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Your comment will be reviewed and published at the journal's discretion. et al. , Gordon C The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. Ann Rheum Dis 2011;70:54-9. physician global assessment Latest Research Papers | ScienceGate The index assesses separately eight organ-based systems. , Ravelli A , Raeisi A Barr et al. PDF Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv , Skogh T Construct validity. Unauthorized use of these marks is strictly prohibited. A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators. , Chan KL Observed and articulated management issues and responses. , Arora S 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. , Mina R Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7]. doi:10.1136/ rmdopen-2017-000578 Prepublication history and Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. , Trendelenburg M What Does It Mean to Be a British Isles Lupus Assessment Group-Based Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. , Wallace DJ Results. How should lupus flares be measured? Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. , Block JA The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Carpenter AB The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Birmingham DJ . , Urowitz MB. et al. The last MEDLINE search was performed on 1 July 2019. Mok CC Supporting the face validity property, PGA was defined the gold standard in 11 studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88] and in 32 it was used as the reference to which other activity scores were compared, such as the SLEDAI [4, 10, 13, 25, 27, 28, 31, 33, 35, 36, 41, 46, 47, 50, 51, 53, 62, 65, 68, 72, 73, 76, 81, 9699], BILAG [4, 27, 35, 36, 46, 65, 72, 73, 81, 98], SLAM [4, 72, 76, 99], LAI [68, 88], patient global assessment [81, 83, 84] and ECLAM [35]. While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. , Seaman AL SLE or at an SLE site, but only if the injury requires treatment by a licensed medical doctor. Published by Oxford University Press on behalf of the British Society for Rheumatology. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. , Dietzmann K Once two investigators (E.C., M.P.) Liang MH 2. et al. An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). Derivatives RWA Production Controller (SA-CCR/SLE) Complement-Targeted Therapeutics Market Report (2022 to , Liberati A , Fang H , Mohan C. Jolly M PGA or SGA described in ePROVIDE - Mapi Research Trust Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. et al. et al. We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. et al. , Rodrigues M Your recommendations as to what might or should be done in relation to various issues observed. Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. Neuropsychiatry OXFORD TEXTBOOKS IN PSYCHIATRY Oxford Textbook of Neuropsychiatry Edited by Niruj Agrawal, Rafey Faruqui, and Mayur Bodani Oxford Textbook of Psychiatry of Intellectual Disability Edited by Sabyasachi Bhaumik and Regi Alexander Oxford Textbook of Inpatient Psychiatry Edited by Alvaro Barrera, Caroline Attard, and Rob Chaplin Oxford Textbook of Attention . The Author(s) 2020. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). , Ko T X 20 sentence examples within Physician Global Assessment. , Borghoff K , Wallace DJ BATCH RUBY INTENSIVE REVIEWRTRMF 3. Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). BICLA responders had fewer lupus-related serious .